SELANK

Frequently Researched Together

Neuropeptide research compounds

Molecular Profile

What Is Selank?

Synthetic heptapeptide analog of tuftsin, an immunomodulatory tetrapeptide derived from IgG

HeptapeptideTuftsin AnalogTypeSynthetic heptapeptideCAS Number129954-34-3Molecular FormulaC33H57N11O9Molecular Weight751.9 g/molAmino Acids7 residuesSequenceThr-Lys-Pro-Arg-Pro-Gly-ProPubChem Database

Storage Requirements

Stability Information

Handle with care to maintain potency

Light sensitiveTemperature sensitive❄️Lyophilized (powder)-20°C•protect from light Reconstituted2-8°C Nasal spray (0.15%)2-8°C•30 days after opening

Development Status

Regulatory Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

DeveloperRussian Academy of SciencesCollaboratorV.V. Zakusov InstituteApprovalRussia (2009), UkraineIndicationGeneralized Anxiety DisorderUS StatusNot FDA-approvedFormulation0.15% nasal drops (Rx in Russia)ClinicalTrials.gov

Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia

2008•PMID: 18454096

Zozulia AA, Neznamov GG, Siuniakov TS, et al.

View SourceBehavioural Neurology

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

2017•DOI: 10.1155/2017/5091027•PMID: 28280289

Kasian A, Kolomin T, Andreeva L, et al.

View SourceFrontiers in Pharmacology

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

2016•DOI: 10.3389/fphar.2016.00031•PMID: 26924987

Volkova A, Shadrina M, Kolomin T, et al.

View SourceBulletin of Experimental Biology and Medicine

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

2019•PMID: 31625062

Kozlovskii II, Andreeva LA, Myasoedov NF

View SourceZhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders

2014•PMID: 25176261

Medvedev VE, Tereshchenko ON, Israelian AIu, et al.

View SourceBulletin of Experimental Biology and Medicine

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity

2001•PMID: 11550013

Zozulya AA, Kost NV, Yu Sokolov O, et al.

View SourceBulletin of Experimental Biology and Medicine

The Influence of Selank on the Level of Cytokines Under Conditions of Experimental Immunodeficiency

2020•PMID: 32621722View SourcePharmacokinetic Data

Selank Intranasal Bioavailability Studies

View SourcePubChem Database

Selank – Compound Summary

View Source