What Is 5-Amino-1MQ?
TypeSmall molecule NNMT inhibitorCAS Number42464-96-0Molecular Weight159.21 g/mol (cation)Salt Form286.11 g/mol (iodide salt)FormulaC₁₀H₁₁N₂⁺ (cation)AppearanceBrown to reddish-brown solidPubChem / J. Med. Chem. 2017
5-Amino-1MQ
$49.99
A selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that modulates NAD+ salvage and lipogenesis pathways in preclinical metabolic research models. Premium Research Peptide.
1000 in stock
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Frequently Researched Together
Metabolic & NAD+ pathway research
Stability Information
Soluble in DMSOAvoid repeated freeze-thawAliquot after reconstitution❄️Lyophilized (powder)-20°C•stable 24+ months Short-term storage2-8°C•up to 30 days Reconstituted2-8°C
Journal of Medicinal Chemistry
Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase
2017•DOI: 10.1021/acs.jmedchem.7b00389•PMID: 28548833
Neelakantan H, Wang HY, Vance V et al.
View SourceBiochemical Pharmacology
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
2018•DOI: 10.1016/j.bcp.2017.11.007•PMID: 29155147
Neelakantan H, Vance V, Wetzel MD et al.
View SourceBiochemical Pharmacology
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle
2019•DOI: 10.1016/j.bcp.2019.02.008•PMID: 30753815
Neelakantan H, Brightwell CR, Graber TG et al.
View SourceScientific Reports
Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice
2021•DOI: 10.1038/s41598-021-85051-6•PMID: 33707534
Sampson CM, Dimet AL, Neelakantan H et al.
View SourceJournal of Pharmaceutical and Biomedical Analysis
Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies
2021•DOI: 10.1016/j.jpba.2021.114255•PMID: 34304009
Awosemo O, Neelakantan H, Watowich S et al.
View SourceJournal of Obstetrics and Gynaecology
Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells
2021•DOI: 10.1080/01443615.2020.1854696•PMID: 33645410
Akar S, Duran T, Azzawri AA et al.
View SourceScientific Reports
Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
2022•DOI: 10.1038/s41598-021-03670-5•PMID: 35013352
Dimet-Wiley A, Wu Q, Wiley JT et al.
View SourceDiabetes, Obesity and Metabolism
Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction
2024•DOI: 10.1111/dom.15879•PMID: 39161060
Babula JJ, Bui D, Stevenson HL et al.
View Source
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